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Test Code CMVP Cytomegalovirus (CMV) Antibodies, IgM and IgG, Serum

Additional Codes

Sunquest: CMVPM

EPIC: LAB5758

Reporting Name

Cytomegalovirus Ab, IgM and IgG, S

Useful For

Aiding in the diagnosis of acute or past infection with cytomegalovirus (CMV)

 

Determining prior exposure to CMV

 

This test should not be used for screening blood or plasma donors.

Profile Information

Test ID Reporting Name Available Separately Always Performed
CMVM Cytomegalovirus Ab, IgM, S Yes Yes
CMVG Cytomegalovirus Ab, IgG, S Yes Yes

Method Name

Multiplex Flow Immunoassay (MFI)

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Supplies: Sarstedt Aliquot Tube 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Minimum Volume

0.8 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject
Heat-inactivated specimen Reject

Reference Values

CYTOMEGALOVIRUS IgM:

Negative

 

CYTOMEGALOVIRUS IgG:

Negative

 

Reference values apply to all ages.

Day(s) Performed

Monday through Saturday

CPT Code Information

86644-CMV, IgG

86645-CMV, IgM

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CMVP Cytomegalovirus Ab, IgM and IgG, S 87424-8

 

Result ID Test Result Name Result LOINC Value
CMVG Cytomegalovirus Ab, IgG, S 13949-3
CMVM Cytomegalovirus Ab, IgM, S 24119-0

Clinical Information

Cytomegalovirus (CMV) is a member of the Herpesviridae family of viruses and usually causes asymptomatic infection after which it remains latent in patients, primarily within bone marrow derived cells. Primary CMV infection in immunocompetent individuals may manifest as a mononucleosis-type syndrome, similar to primary Epstein-Barr virus infection, with fever, malaise and lymphadenopathy.

 

Cytomegalovirus is a significant cause of morbidity and mortality among bone marrow or solid organ transplant recipients, individuals with AIDS, and other immunosuppressed patients due to virus reactivation or from a newly acquired infection. Infection in these patient populations can affect almost any organ and lead to multiorgan failure. CMV is also responsible for congenital disease among newborns and is one of the TORCH infections (toxoplasmosis, other infections including syphilis, rubella, CMV, and herpes simplex virus).

 

Cytomegalovirus seroprevalence increases with age. In the United States, the prevalence of CMV-specific antibodies increases from approximately 36% in children from 6 to 11 years old to over 91% in adults over 80 years old.

Specimen Retention Time

14 days

Report Available

Same day/1 to 3 days

Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.