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HelpTest Code CRU Chromium, 24 Hour, Urine
Reporting Name
Chromium, 24 Hr, UUseful For
Screening for occupational exposure to chromium
Monitoring metallic prosthetic implant wear
Method Name
Triple-Quadrupole Inductively Coupled Plasma Mass Spectrometry (ICP-MS/MS)
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
UrineOrdering Guidance
Necessary Information
24-Hour volume (in milliliters) is required.
Specimen Required
Patient Preparation: High concentrations of gadolinium and iodine are known to potentially interfere with most inductively coupled plasma mass spectrometry-based metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Supplies: Urine Tubes, 10 mL (T068)
Collection Container/Tube: Clean, plastic urine container with no metal cap or glued insert
Submission Container/Tube: Plastic, 10-mL urine tube or clean, plastic aliquot container with no metal cap or glued insert
Specimen Volume: 0.5 mL
Collection Instructions:
1. Collect urine for 24 hours.
2. Refrigerate specimen within 4 hours of completion of 24-hour collection.
3. See Metals Analysis Specimen Collection and Transport for complete instructions.
Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collections.
Specimen Minimum Volume
0.3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine | Refrigerated (preferred) | 28 days |
| Ambient | 28 days | |
| Frozen | 28 days |
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Special Instructions
Reference Values
0-17 years: Not established
≥18 years: 0.1-1.2 mcg/24 hours
Day(s) Performed
Monday
CPT Code Information
82495
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CRU | Chromium, 24 Hr, U | 5624-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 8593 | Chromium, 24 Hr, U | 5624-2 |
| TM44 | Collection Duration (h) | 13362-9 |
| VL42 | Volume (mL) | 3167-4 |
Clinical Information
Chromium (Cr) exists in valence states. Hexavalent chromium (Cr[6+]) and trivalent chromium (Cr[3+]) are the 2 most prevalent forms. Cr(6+) is used in industry to make chromium alloys including stainless steel, pigments, and electroplated coatings. Cr(6+), a known carcinogen, is immediately converted to Cr(3+) upon exposure to biological tissues. Cr(3+) is the only chromium species found in biological specimens.
Urine chromium concentrations are likely to be increased above the reference range in patients with metallic joint prosthesis. Prosthetic devices produced by DePuy Company, Dow Corning, Howmedica, LCS, PCA, Osteonics, Richards Company, Tricon, and Whiteside typically are made of chromium, cobalt, and molybdenum. This list of products is incomplete, and these products change occasionally; see prosthesis product information of each device for composition details.