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Test Code DLAC D-Lactate, Plasma

Reporting Name

D-Lactate, P

Useful For

As an adjunct to urine D-lactate (preferred) for the diagnosis of D-lactate acidosis

Method Name

Gas Chromatography Mass Spectrometry (GCMS) Stable Isotope Dilution Analysis

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Plasma NaFl-KOx


Ordering Guidance


Urine is the preferred specimen for D-lactate determination, order DLAU / D-Lactate, Urine.

 

For determination of L-lactate (lactic acid), order LACS1 / Lactate, Plasma



Specimen Required


Supplies: Sodium Fluoride/Potassium Oxalate Tube, 2 mL (T275)

Collection Container/Tube:

Preferred: Sodium fluoride/potassium oxalate tube

Acceptable: Green top (sodium heparin)

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge, aliquot plasma into a plastic vial, and freeze immediately.

NOTE: If collecting in sodium heparin tubes, centrifugation must occur within one hour of collection.


Specimen Minimum Volume

0.15 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma NaFl-KOx Frozen (preferred) 91 days
  Ambient  91 days
  Refrigerated  91 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

0.0-0.25 mmol/L

Day(s) Performed

Monday, Thursday

CPT Code Information

83605

LOINC Code Information

Test ID Test Order Name Order LOINC Value
DLAC D-Lactate, P 14045-9

 

Result ID Test Result Name Result LOINC Value
8878 D-Lactate, P 14045-9

Clinical Information

D-lactate is produced by bacteria residing in the colon when carbohydrates are not completely absorbed in the small intestine. When large amounts of D-lactate are present, individuals can experience metabolic acidosis, altered mental status (from drowsiness to coma), and a variety of other neurologic symptoms, in particular dysarthria and ataxia. Although a temporal relationship has been described between elevations of plasma and urine D-lactate and the accompanying encephalopathy, the mechanism of neurologic manifestations has not been elucidated.

 

D-lactic acidosis is typically observed in patients with a malabsorptive disorder, such as short-bowel syndrome, or following a jejunoileal bypass. In addition, healthy children presenting with gastroenteritis may also develop the clinical presentation of D-lactic acidosis.

 

Routine lactic acid determinations in blood will not reveal abnormalities because most lactic acid assays measure only L-lactate. Accordingly, D-lactate analysis must be specifically requested (eg, this test). However, as D-lactate is readily excreted in urine, it is the preferred specimen for D-lactate determinations; see DLAU / D-Lactate, Urine.

Specimen Retention Time

1 month

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

Report Available

3 to 6 days