Test Code FL Fluoride, Plasma
Reporting Name
Fluoride, PUseful For
Assessing accidental fluoride ingestion
Monitoring patients receiving sodium fluoride for bone disease or patients receiving voriconazole therapy
Method Name
Ion-Selective Electrode (ISE)
Performing Laboratory
Mayo Clinic Laboratories in RochesterSpecimen Type
Plasma HeparinSpecimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Green top (sodium heparin)
Submission Container/Tube: Plastic vial
Specimen Volume: 3 mL
Collection Instructions: Centrifuge and aliquot plasma into a plastic vial. Glass tubes are not acceptable.
Specimen Minimum Volume
1.2 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Plasma Heparin | Refrigerated (preferred) | 14 days | |
Ambient | 14 days | ||
Frozen | 14 days |
Reject Due To
Gross hemolysis | OK |
Gross lipemia | OK |
Gross icterus | OK |
Reference Values
<4.1 mcmol/L
Day(s) Performed
Tuesday
CPT Code Information
82735
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
FL | Fluoride, P | 14726-4 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
8641 | Fluoride, P | 14726-4 |
Clinical Information
Fluoride induces bone formation by stimulating osteoblasts. Because fluorides increase bone density, they are used in dental preparations and as an antiosteoporotic agent. However, prolonged high exposure to fluoride produces changes in bone morphology consistent with osteomalacia, including prolonged mineralization lag time and increased osteoid thickness. The adverse skeletal effects of fluoride are associated with plasma fluoride greater than 4 mcmol/L. Chronic fluorosis may produce osteosclerosis, periostitis, calcification of ligaments and tendons, and crippling deformities.
Prolonged exposure to the fluoride-containing antifungal agent voriconazole can produce high plasma fluoride concentrations and bone changes (periostitis). Several other medicines also contain fluoride are used for treating skin diseases (eg, flucytosine, an antifungal) and some cancers (eg, fluorouracil, an antimetabolite).