Reference Values

Age <50 years:                     0-450 pg/ml

Age 50-75 years:                  0-900 pg/ml

Age>75 years:                      0-1800 pg/ml

·    In patients with dyspnea, a proBNP level < 300 pg/ml effectively rules out acute CHF with almost 99% negative predictive value.

·    Knowledge of each individual patient’s pro-BNP “baseline” level may be more useful than trying to apply similar cut-offs for every patient. 

·    Marked elevations in NT-pro-BNP may be observed in states other than left ventricular congestive failure, including: acute coronary syndrome; right heart strain/failure (including PE); critical illness; renal failure; as well as advancing age.  Falsely low proBNP in CHF patients may be observed with obesity.